NMR contrast agents

Details NMR contrast agents NMR contrast agents

1987-09-29

1988-07-26

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C101447

Patent

active

047601736

ABSTRACT:
There are provided NMR contrast agents comprising water-soluble paramagnetic metal chelates, preferably of Cr(III), Fe(III) or Gd(III), wherein the chelating entity is an anilide group containing organic moiety, preferably a compound of formula I ##STR1## wherein R.sup.1 to R.sup.5 may represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups. The agents are especially suitable for use in NMR imaging of the hepatobiliary system.

REFERENCES:
patent: 4318898 (1982-03-01), Molter et al.
patent: 4418208 (1983-11-01), Nunn et al.
patent: 4612185 (1986-09-01), Dean
Loberg et al., "Development of New Radiopharmaceuticals . . . ", Radiochemistry and Radiopharmaceuticals, 17,7,633-638.
Nunn et al., "A Structure-Distribution-Relationship Approach . . . ", J. Nucl. Med., 24: 423-430, 1983.

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