Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2006-12-05
2006-12-05
Moran, Marjorie A. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C505S844000
Reexamination Certificate
active
07146277
ABSTRACT:
Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and improving the binding affinity of ligands for biological targets are disclosed. One aspect of the method includes preparing first NMR spectra of a first complex comprising the biological target and a paramagnetically labeled derivative of a first ligand, preparing a second NMR spectra of a second complex comprising the biological target and a second ligand, and analyzing the spectra to determine whether the second ligand binds to the biological target within the paramagnetic zone of the paramagnetically labeled derivative. The first and second steps may be performed simultaneously, consecutively, or in any order.
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Al-Hashimi Hashim M.
Jain Nitin U.
Morris Laura C.
Prestegard James H.
Venot Andre P.
Clow Lori A.
King & Spalding LLP
Moran Marjorie A.
Prestegard James H.
Sullivan Clark G.
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