NMR-assayable ligand-labelled trifluorothymidine containing comp

Details NMR-assayable ligand-labelled trifluorothymidine containing comp NMR-assayable ligand-labelled trifluorothymidine containing comp

1988-05-26

1991-10-01

Rosen, Sam

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 436173, 436806, 435 5, A61K 4300, A61K 4902

Patent

active

050532154

ABSTRACT:
A method for diagnosing HSV infections in human or non-human patients which involves intravenously administering to the patient a non-invasively assayable ligand-labelled anti-viral drug, wherein the drug is a compound which is phosphorylated bby the HSV-induced thymadine kinase present in HSV-infected cells to a phosphorylated assayable ligand-labelled compound which cannot diffuse from within the infected cells and then non-invasively assasying the presence or absence of the accumulated phosphorylated compound present therein.
A pharmaceutical composition in intravenously administrable form and adapted for the diagnosis of HSV infection which is a mixture of a non-invasively assayable ligand-labelled anti-viral drug and a pharmaceutically acceptable carrier therefor.

REFERENCES:
patent: 3201387 (1965-08-01), Heidelberger
patent: 4210638 (1980-07-01), Goeer
patent: 4675287 (1987-06-01), Reisfeld
Rand et al., "Trifluorothymidine: Potential Non-Invasive Diagnosis of Herpes Simplex Infection . . . ", J. Virol. Methods 18, 257-270 (1987).
Chemical Abstracts, vol. 108(13), Abst. 109067b, p. 319, 3/28/88, Hand et al., "Trifluorothymidine: Potential Non-Invasive Diagnosis of Herpes Simplex Infection . . . ", J. Virol. Methods 18(4), 257-69 (1987).
Fischer et al., Mol. Pharmacol., vol. 24, No. 1, "Preferential Inhibition of 5-Trifluoromethyl-2'-Deoxyuridine Phosphorylation by 5'-Amino-5'-Deoxythymidine in Uninfected Versus Herpes Simplex Virus-Infected Cells", pp. 90-96 (Jul. 1983).

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