NM03 antibody materials and methods

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303879, 435331, 4353391, 4241481, C07K 1608, C07K 1610, C12P 2108

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active

056189222

ABSTRACT:
The present invention provides a monoclonal antibody, designated NM03, which specifically binds HIV-1 gp 120.

REFERENCES:
patent: 5019387 (1991-05-01), Haynes et al.
Akerblom et al., "Neutralizing cross-reactive and non-neutralizing monoclonal antibodies to HIV-1 gp120", AIDS, 4:953-960 (1990).
Albovini et al., Eds., "Detection of HIV in Clinical Specimens", pp. 15-29 in Techniques in HIV Research, Stockton Press, New York, New York (1990).
Durda et al., "HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide", AIDS Research and Human Retroviruses, 6:1115-1123 (1990).
Emini et al., "Prevention of HIV-1 Infection in Chimpanzees by gp120 V3 Domain-Specific Monoclonal Antibody", Nature, 335:728-730 (1992).
Godding, "Antibody Production by Hybridomas", J. Immunol. Meth., 39:285-308 (1980).
Goudsmit et al., "Human Immunodeficiency Virus Type 1 Neutralization Epitome With Conserved Architecture Elicits Early Type-Specific Antibodies in Experimentally Infected Chimpanzees", Proc. Natl. Acad. Sci. USA, 85:4478-4482 (1988).
Haigwood et al., "Evidence for Neutralizing Antibodies Directed Against Conformational Epitopes of HIV-1 gp120", Vaccines, 90:313-320 (1990).
Ho et al., "Conformational Epitope on gp120 Important in CD4 Binding and Human Immunodeficiency Virus Type 1 Neutralization Identified by a Human Monoclonal Antibody", J. Virol., 65(1);489-493 (1991).
Ho et al., "Second Conserved Domain of gp120 Is Important for HIV Infectivity and Antibody Neutralization", Science, 239:1021-1023 (1988).
Holley et al., "Prediction of Optimal Peptide Mixtures to Induce Broadly Neutralizing Antibodies to Human Immunodeficiency Virus Type 1", Proc. Natl. Acad. Sci. USA, 85:6800-6804 (1991).
Jackson et al., "Passive Immunoneutralisation of Human Immunodeficiency Virus in Patients with Advanced AIDS", Lancet, 2:647-652 (1988).
Javaherian et al., "Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1", Science, 250: 1590-1593 (1990).
Javaherian et al., "Principal Neutralizing Domain of the Human Immunodeficiency Virus Type I Envelope Protein", Proc. Natl. Acad. Sci. USA, 86:6768-6772 (1989).
Karpas et al., "Effects of Passive Immunization in Patients with the Acquired Immunodeficiency Syndrome-Related Complex and Acquired Immunodeficiency Syndrome", Proc. Natl. Acad. Sci. USA, 85:9234-9237 (1988).
LaRosa et al., "Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant", Science, 249:932-935 (1990).
Lasky et al., "Neutralization of the AIDS Retrovirus by Antibodies to a Recombinant Envelope Glycoprotein", Science, 233: 209-212 (1986).
Liou et al., "A Chimeric Mouse-Human Antibody that Retains Specificity for HIV gp120 and Mediates the Lysis of HIV-Infected Cells", J. Immunol., 143(12):3967-3975 (1989).
Matsushita et al., "Characterization of a Human Immunodeficiency Virus Neutralizing Monoclonal Antibody and Mapping of the Neutralizing Epitope", J. Virol., 62:2107-2114 (1988).
McCune, "HIV-1: The Infective Process in Vivo", Cell, 645:351-363 (1991).
Ohno et al., "A broadly neutralizing monoclonal antibody that recognizes the V.sub.3 region of human immunodeficiency virus type 1 glycoprotein gp120", Proc. Natl. Acad. Sci. USA, 88:10726-10729 (1991).
Oi and Herzenberg, "Immunoglobulin-Producing Hybrid Cell Lines", Selected Methods Cell Immunology: 351-372 (1979).
Palker et al., "Type-specific Neutralization of the Human Immunodeficiency Virus with Antibodies to Env-encoded Synthetic Peptides", Proc. Natl. Acad. Sci. USA, 85:1932-1936 (1988).
Putney et al., "HTLV-III/LAV-Neutralizing Antibodies to an E. Coli-Produced Fragment of the Virus Envelope", Science, 234:1392-1395 (1986).
Rusche et al., "Antibodies That Inhibit Fusion of Human Immunodeficiency Virus-Infected Cells Bind a 24-Amino Acid Sequence of the Viral Envelope", Proc. Natl. Acad. Sci. USA, 85:3198-3202 (1988).
Scott et al., "Human Monoclonal Antibody That Recognizes the V3 Region of Human Immunodeficiency Virus gp120 and Neutralizes the Human T-Lymphoctropic", Proc. Natl. Acad. Sci. USA, 87:8597-8601 (1990).
Weiss et al., "Variable and Conserved Neutralization Antigens of Human Immunodeficiency Virus", Nature, 324:572-575 (1986).
Cohen Science vol. 264. 20 May 1994 p. 1072.
Fahey et al. Clin Exp. Immunol. 1992 88 1-5.

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