[Nle.sup.8, Nle.sup.18, Tyr.sup.34 or Phe.sup.34 ]-h-PTH peptide

Details [Nle.sup.8, Nle.sup.18, Tyr.sup.34 or Phe.sup.34 ]-h-PTH peptide [Nle.sup.8, Nle.sup.18, Tyr.sup.34 or Phe.sup.34 ]-h-PTH peptide

1984-08-06

1987-04-07

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

424 11, 436545, C07K 710, A61K 4300, G01N 33534

Patent

active

046562508

ABSTRACT:
A peptide of the formula ##STR1## wherein A is Tyr or Phe, or a pharmaceutically acceptable salt thereof, is useful for the diagnosis of parathyroid gland function. When A is Tyr, the peptide can be labelled with iodine-125 without losing its PTH activity and without undergoing oxidation upon storage.

REFERENCES:
patent: 3886132 (1975-05-01), Brewer et al.
patent: 4086196 (1978-04-01), Tregear
patent: 4369138 (1983-01-01), Lindall
Chem. Abstr., vol. 97, (1982) 182837.
Chem. Abstr., vol. 91, (1979) 151634.
Derwent Abstr. J5-5113-753, 2/22/79.
Howard Rasmussen and Lyman C. Craig, "Parathyroid Hormone"; The Parathyroid Polypeptides; The Rockefeller Institute, New York, N.Y., Recent Program Hormone Research; 1962; pp. 269-295.
J. T. Potts, Jr., et al., "Synthesis of a Biologically Active N-Terminal Tetratriacontapeptide of Parathyroid Hormone": Proceedings of the National Academy of Sciences; vol. 8, No. 1, 1971, pp. 63-67.

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