NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depres

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

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800 3, 800 13, 800 9, 800 21, 800 22, 800 25, 435 4, 435 6, 435 921, 435455, 435462, 435463, 424 921, 424 9321, 514 44, C12N 1509, C12N 1563, C12N 1500, C12N 500

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061275980

ABSTRACT:
The present invention features mouse models for Nkx-2.2 gene function and for Nkx-6.1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2.2 gene function or a defect in Nkx-6.1 gene function (where, because Nkx-2.2 acts upstream of Nkx-6.1, a defect in Nkx-2.2 gene function affects Nkx-6.1 gene function) and by having a decreased number of insulin-producing cells relative to a normal mouse. Where the transgenic mouse contains a defect in Nkx-2.2 gene function, the mouse is further characterized by a decreased number of serotonin-producing cells relative to a normal mouse. The transgenic mice may be either homozygous or heterozygous for the Nkx-2.2 or Nkx-6.1 defect.

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