Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-07-25
2000-10-03
Chambers, Jasemine
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 3, 800 13, 800 9, 800 21, 800 22, 800 25, 435 4, 435 6, 435 921, 435455, 435462, 435463, 424 921, 424 9321, 514 44, C12N 1509, C12N 1563, C12N 1500, C12N 500
Patent
active
061275980
ABSTRACT:
The present invention features mouse models for Nkx-2.2 gene function and for Nkx-6.1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2.2 gene function or a defect in Nkx-6.1 gene function (where, because Nkx-2.2 acts upstream of Nkx-6.1, a defect in Nkx-2.2 gene function affects Nkx-6.1 gene function) and by having a decreased number of insulin-producing cells relative to a normal mouse. Where the transgenic mouse contains a defect in Nkx-2.2 gene function, the mouse is further characterized by a decreased number of serotonin-producing cells relative to a normal mouse. The transgenic mice may be either homozygous or heterozygous for the Nkx-2.2 or Nkx-6.1 defect.
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German Michael S.
Hartigan-O'Connor Dennis J.
Meneses Juanito J.
Pedersen Roger A.
Rubenstein John L.R.
Chambers Jasemine
Francis Carol. L.
Martin Jill D.
The Regents of the University of California
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