NK1 antagonists

Details NK1 antagonists NK1 antagonists

2006-10-17

2006-10-17

Raymond, Richard (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C540S450000, C540S451000, C540S453000, C540S466000, C540S531000, C540S543000, C540S609000, C546S016000, C546S019000, C546S020000, C546S229000, C546S236000, C514S079000, C514S085000, C514S091000, C548S408000, C548S410000

Reexamination Certificate

active

07122677

ABSTRACT:
A NK1antagonist having the formula (I),wherein Ar1and Ar2are optionally substituted phenyl or heteroaryl, X1is an ether, thio or imino linkage, R4and R5are not both H or alkyl, and the remaining variables are as defined in the in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceuticals compositions. Methods of treatment and combinations with other agents are also disclosed.

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