NK-2 homeobox transcription factor

Details NK-2 homeobox transcription factor NK-2 homeobox transcription factor

2007-02-27

2007-02-27

Siew, Jeffrey (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C530S350000

Reexamination Certificate

active

10257765

ABSTRACT:
Nkx2-C4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Nkx2-C4 polypeptides and polynucleotides in diagnostic assays.

REFERENCES:
patent: WO 9962940 (1999-12-01), None
Swiss Port Institute for Bioinformatics (Geneva Switzerland, Accession No. P43688, 1998).
Uniprot database for proteins (Swiss Institute for Bioinformatics and European Bioinformatics Institution (Geneva Switzerland and Cambridge, UK) Accession No. Q98873, 1997).
Database EMBL ′Online!, Nov. 2, 1999; Birren, B. et al., “Human chromosome 4 clone RP11-213G6,” retrieved from EBI, accession No. AC012574, database accession No. AC012574, XP002175444, abstract.
Database EMBL ′Online!, May 17, 1996; Turbay, D. et al., “Human transcription factor hCsx mRNA,” retrieved from EBI, accession No. HS349621, database accession No. U34962, XP002175445, abstract.
Database EMBL ′Online!, Dec. 22, 1998; Tate, G. et al., “Human NKx-2.5 mRNA,” retrieved from EBI, accession No. AB021133, database accession No. AB021133, XP002175446, abstract.
Database EMBL ′Online!, Oct. 3, 1995; Hamdan, H. et al., “Human thyroid transcription factor-1 (TIF-1) mRNA,” retrieved from EBI, accession No. HS337491, Database Accession No. U33749, XP002175447, abstract.
Schott et al., “Congenital heart disease caused by mutations in the transcription factor NKX2-5,” Science, Jul. 3, 1998, pp. 108-111, vol. 281, XP002125587, ISSN: 0036-8075, cited in the application, the whole document, Washington, US.
Ivens A et al., “The human homeobox gene HOX7 maps to chromosome 4P16.1 and may be implicated in Wolf-hirschhorn syndrome,” Human Gentics, 1990, pp. 473-476, vol. 84, No. 5, XP000926612, ISSN: 0340-6717, abstract.

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