NK 1 antagonists

Details NK 1 antagonists NK 1 antagonists

2011-03-08

2011-03-08

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S317000

Reexamination Certificate

active

07902366

ABSTRACT:
A NK1antagonist having the formula (I),wherein Ar1and Ar2are optionally substituted phenyl or heteroaryl, X1is an ether, thio or imino linkage, R4and R5are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

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