Nizatidine preparation

Details Nizatidine preparation Nizatidine preparation

1998-02-02

1999-11-09

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27730

Patent

active

059817577

ABSTRACT:
Nizatidine is prepared by reacting N-[2-[[[2-(hydroxymethyl)-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro -1,1-ethenediamine, with an aryl- or tert.alkyl-sulfonyl halide in the presence of a tertiary amine base and a sulfonation catalyst to form the corresponding sulfonate ester, reacting the sulfonate ester so formed with an excess of dimethylamine, and recovering the nizatidine so formed.

REFERENCES:
patent: 5541335 (1996-07-01), Manning
patent: 5574054 (1996-11-01), Kitagawa et al.
patent: 5700945 (1997-12-01), Manning
Maria Altamura and Enzo Perrotta, An Efficient Synthesis of 2-(Halogenomethyl)penems, J. Org. Chem., 1993, 58, 272-274.
Mar., Advanced Organic Chemistry 4th ed. p. 353, 1992.

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