Nitroxide radioprotector formulations and methods of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07625928

ABSTRACT:
Pharmaceutical compositions useful in preventing and treating negative side effects accompanying radiotherapy are disclosed. More particularly, new formulations that can be applied to the skin and mucous membranes of patients undergoing radiotherapy and methods of using these formulations are disclosed.

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Goffman, Thomas, et al. “Topical Application of Nitroxide Protects Radiation-Induced Alopecia in Guinea Pigs”, International Journal of Radiation Oncology Biology Physics, 1992; vol. 22, No. 4; pp. 803-806.
Cuscela, Daniel, et al. “Protection from Radiation-Induced Alopecia with Topical Application of Nitroxides: Fractionated Studies”, The Cancer Journal from Scientific American, 1996; vol. 2, No. 5, pp. 273-278.
Roberts, Dianna B., et al. “Acemannan-Containing Wound Dressing Gel Reduces Radiation-Induced Skin Reaction in C3H Mice”, International Journal of Radiation Oncology Biology Physics, 1995; vol. 32, No. 4; pp. 1047-1052.
Yanagimoto, Go, et al. “Skin Disposition of Drugs After Topical Application in Hairless Rats”, Biosciences Information Service ,1999; Abstract.
Supplementary European Search Report, Sep. 16, 2008.

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