Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-02-26
1992-04-14
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 514424, 548542, G01N 3100, G01N 2400, A61K 3140, C07D20746
Patent
active
051046415
ABSTRACT:
Nitroxides useful as NMR contrast enhancing agents for organs are of the formula ##STR1## wherein in the above formulae, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are, g., CH.sub.3 ; R is --B--COO--M.sup.+ or --B--N(alkyl).sub.3 Hal.sup.-, wherein B is a divalent bond or alkylene of 1-8 carbon atoms, M is an ammonium or metal ion and Hal is a halogen atom; are also useful as NMR contrast enhancing agents on joints.
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Hollinden Gary E.
Hollrah Glennon H.
M.R.I., Inc.
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