Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ether doai
Patent
1995-02-13
1997-05-27
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ether doai
514560, 514825, 514859, 514861, 514863, 514880, A61K 31075, A61K 3120
Patent
active
056332840
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to dermatological compositions. The compositions of this invention are suitable to be applied to the human skin for the treatment of a variety of skin, muscular, joint and peripheral circulatory conditions.
BACKGROUND OF THE INVENTION
It is known in the field of dermatology to make use of coal tar preparations in the treatment of certain skin conditions, for example, psoriasis [Hunter J. A. A., Savin J. A. and Dahl M. V., Clinical Dermatology, Blackwell Scientific Publications p.49].
It has also been suggested that essential fatty acids, including evening primrose oil may be used in the treatment of skin conditions such as eczema [see references cited by July Graham, Evening Primrose Oil, Thorsons, pp. 127-128].
Various other compositions are known to be used in the treatment of these and other skin conditions.
OBJECT OF THE INVENTION
It is an object of the present invention to provide novel dermatologlcal compositions.
SUMMARY OF THE INVENTION
According to the present invention there is provided a dermatological composition having as active ingredients nitrous oxide and at least one essential fatty acid or ester thereof selected from the group consisting of linoleic acid, arachidonic acid, linolenic acid, gamma-linolenic acid, and the lower alkyl esters thereof in a dermatologically acceptable carrier.
The composition may further include one or more supplementary ingredients selected from the group consisting of Liquor Picis Carbonis [also known as coal tar solution], collagen, nicotinamide, nicotinic acid, lanolin, vitamin E, methyl salicylate, and known H.sub.1 -antagonist antihistamines.
In the preferred form of the invention the composition is saturated with nitrous oxide.
Also in the preferred form of the invention the essential fatty acid component of the composition comprises a mixture of esters of the fatty acids listed above. Thus in the most preferred form of the invention the fatty acid component of the composition is constituted by the complex known as Vitamin F and in this regard it is preferred to make use of the ester form of Vitamin F known as Vitamin F Ethyl Ester. This product is commercially available under the trade description of Vitamin F Ethyl Ester CLR 110 000 Sh.L. U./g from CLR Chemicals Laboratorium Dr. Kurt Richter GmbH, of Berlin, Germany. The typical fatty acid distribution of this product is as follows:
______________________________________ <C.sub.16 0%
C.sub.16-0 8,3%
C.sub.18-0 3,5%
C.sub.18-1 21,7%
C.sub.18-2 34,8%
C.sub.18-3 28,0%
>C.sub.18 1,6%
unknown 2,1%
______________________________________
In one preferred form of the invention the composition comprises only coal tar solution as a supplementary active ingredient. In this form of the invention the composition is useful in the treatment of psoriasis, fever blisters, herpes simplex, shingles, chicken pox and eczematous conditions of the skin and scalp.
In another form of the invention the composition comprises coal tar solution in combination with one of collagen, nicotinamide, and lanolin. In these forms of the invention the composition has been shown to be useful for the treatment of ache, conditions involving poor peripheral circulation, such as chilblains, and uhthyoses respectively.
In an alternative form of the invention the composition may contain coal tar solution in combination with an antihistamine selected from the H.sub.1 -antagonist group and be used for the treatment of atopic and allergic conditions manifesting in skin irritations, such as eczema, dermatitis and ringworm.
In a further form of the invention the supplementary ingredient may comprise methyl salicylate in which form the composition is useful in the treatment of muscle and joint pains.
The composition may finally comprise collagen and lanolin as supplementary ingredients in which form it is useful in cosmetic preparations, or for the treatment of alopecia or minor skin ailments, such as chloasmas.
The composition may be formulated to have any dermatologically
Dodson Shelley A.
Pitmy International N.V.
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