Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-04-21
1997-03-18
Cain, Edward J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
524 14, 524 15, 524 16, 524 17, 530324, 530325, 530326, 530327, 530328, 530329, A61K 3700
Patent
active
056123140
ABSTRACT:
Neuropeptides, particularly vasoactive intestinal peptide(VIP) and fragments, mutations and derivatives thereof that have corresponding activities to which have been directly or indirectly linked at least one NO or NO.sub.2 group, and their uses, including the relaxation of smooth muscle in several tissues, including vascular smooth muscle (e.g., aorta) and nonvascular smooth muscle (e.g. trachea, sphincter of Oddi, gastrointestinal smooth muscle and corpus cavernosum smooth muscle), and particularly also for the diagnosis and treatment of human male impotence.
REFERENCES:
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5439938 (1995-08-01), Snyder et al.
patent: 5508045 (1991-04-01), Harrison et al.
de Tejada Inigo S.
Stamler Jonathan
Brigham & Women's Hospital
Cain Edward J.
Herron Charles J.
Olstein Elliot M.
Trustees of Boston University
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