Nitrosoureas compounds preparation thereof and utilization there

Details Nitrosoureas compounds preparation thereof and utilization there Nitrosoureas compounds preparation thereof and utilization there

1990-01-02

1991-03-19

Elmore, Carolyn S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564 33, C07C27568, A61K 3117

Patent

active

050011588

ABSTRACT:
Compounds having the general formula (I), ##STR1## wherein X and Y represent individually H or --NO, at least one of them being a group-NO, n is 0, 1 or 2, R represents hydrogen, an aliphatic, cycloaliphatic, cycloaliphatic-alkyl, aryl or aralkyl radical, or a group of formula, ##STR2## wherein R.sub.1 is a lower alkyl radical or an aryl, all these radicals being optionally substituted. The present invention also relates to the compounds hereabove defined in the form of mixtures of their position isomers. Furthermore, the present invention discloses processes for preparing such compounds, as well as compositions, useful particularly in anticancerous chemotherapy, containing at least one of said compounds as an active principle.

REFERENCES:
Johnston et al, J. of Med. Chem. , vol. 14, No. 7 (1971), pp. 600-614.
Madelmont et al, J. Med. Chem., 1985 28(9), 1346-50.
"Nitrosoureas in Cancer Treatment", B. Serrou, P. Schein and J. L. Imbach, Eds., 1981, 123.
J. Martinez, J. Oriy, J. L. Imbach et F. Winternitz, J. Med. Chem., 1982, 25, 178-182.
R. Maral et Coll. Eur. J. Med. Chem., Soumis Pour Publication (Reference p. 32 de la Demande de Brevet), 1984, 315-318.
French text "Mise a Jour 1986", Madelmont et al along with its English translation.

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