Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1978-10-16
1980-09-02
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 18, 536 22, 536 53, A61K 3170, C07H 506
Patent
active
042206430
ABSTRACT:
Novel nitrosourea compounds are provided which possess a high level of inhibitory activity against leukemia and tumors with a low toxicity and which are therefore useful for pharmaceutical purposes. The compounds have the chemical structure: ##STR1## wherein .about. represents a single bond which may be in the .alpha.- or .beta.-position and are prepared by nitrosating a urea compound of the formula: ##STR2## with a nitrosating agent in a manner known per se.
REFERENCES:
patent: 3767640 (1973-10-01), Suami et al.
patent: 3940383 (1976-02-01), Fujiwara et al.
patent: 4057684 (1977-11-01), Kimura et al.
patent: 4086415 (1978-04-01), Suami et al.
Johnson et al., "Cancer Treatment Reviews," (1975), 2, pp. 1-31.
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