Nitrosourea pentose compounds

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 18, 536 22, 536 53, A61K 3170, C07H 506

Patent

active

042206430

ABSTRACT:
Novel nitrosourea compounds are provided which possess a high level of inhibitory activity against leukemia and tumors with a low toxicity and which are therefore useful for pharmaceutical purposes. The compounds have the chemical structure: ##STR1## wherein .about. represents a single bond which may be in the .alpha.- or .beta.-position and are prepared by nitrosating a urea compound of the formula: ##STR2## with a nitrosating agent in a manner known per se.

REFERENCES:
patent: 3767640 (1973-10-01), Suami et al.
patent: 3940383 (1976-02-01), Fujiwara et al.
patent: 4057684 (1977-11-01), Kimura et al.
patent: 4086415 (1978-04-01), Suami et al.
Johnson et al., "Cancer Treatment Reviews," (1975), 2, pp. 1-31.

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