Nitrosourea derivatives

Details Nitrosourea derivatives Nitrosourea derivatives

1978-01-20

1979-12-25

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

260553R, 424180, 536 4, 536 53, C07H 1520

Patent

active

041806557

ABSTRACT:
New nitrosourea derivatives are provided, which possess a high inhibitory activity against the leukemia and tumors with a low toxicity and which are useful for pharmaceutical purposes. The compounds have the formula ##STR1## wherein A represents a glycosyl group, a monovalent residue of methyl glucoside or of alditol, a N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n is 1, or A represents a tetravalent residue of ribostamycin when n is 4 and R represents a lower alkyl or halo-alkyl group and are prepared by treating a compound of the formula ##STR2## with a nitrosating agent.

REFERENCES:
patent: 3767640 (1973-10-01), Suami et al.
patent: 3940383 (1976-02-01), Fujiwara et al.
patent: 4086415 (1978-04-01), Suami et al.

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