Nitrosourea derivatives

Details Nitrosourea derivatives Nitrosourea derivatives

1982-01-12

1984-06-05

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

564 33, A61K 3117, C07C12716

Patent

active

044528140

ABSTRACT:
Nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formulae (I), (II) and (III): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 may be the same or different and each represent a hydrogen atom or an alkyl, aryl, aralkyl, alkanoyl or a heterocyclic group; R.sup.3 represents the residual group on the .alpha.-carbon atom of an .alpha.-amino acid; n represents 2 or 3; X represents a halogen atom selected from chlorine, fluorine and bromine; and Ac represents an alkanoyl group.

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patent: 4148921 (1979-04-01), Suami
patent: 4335247 (1982-06-01), Takatori et al.
Zeller et al., "Chemotherapeutic Activity of 2-Chloroethylnitrosocarbamoyl Derivatives of Amino Acids in a Transplanted Rat Leukemia" (L5222) Drug Res. 32(I) 1982.
Tang et al., "Synthesis of Potentially Antineoplastic Derivatives of N-[N-(2-Cloroethyl)-N-Nitrosocarbamoyl]Amino Acids" Arch. Pharm., vol. 314, 1981.
Torrence et al. "5-Substituted Uracil Arabinonucleosides as Potential Antiviral Agents", J. of Med. Chem., 1979, vol. 22, No. 3.

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