Nitrosothiol derivatives and their use

Details Nitrosothiol derivatives and their use Nitrosothiol derivatives and their use

1990-08-03

1992-05-26

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142382, 514255, 514357, 514358, 514419, 514538, 514550, 514562, 514593, 544160, 544400, 546331, 548535, 558414, 558436, A61K 3140, A61K 31195, C07D20709, C07C32307

Patent

active

051168618

ABSTRACT:
Novel nitrosothiol derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently a hydrogen atom or a hydrocarbon residue which may be substituted; R.sup.3 is a hydrogen atom, an acyl group or a hydrocarbon residue which may be substituted; X.sup.1 is a hydrogen atom, an acyl group, a lower alkoxy group or a hydrocarbon residue which may be substituted; X.sup.2 is an acyl group or a carboxyl group which may be esterified or which may form an amide; with proviso that when X.sup.2 is a carboxyl group X.sup.1 is not a hydrogen atom or acetyl group and that when both R.sup.1 and R.sup.2 are hydrogen atoms X.sup.1 is not acetyl group or .gamma.-glutamyl group, and salts thereof, show excellent hypotensive action, antiarrhythmic action, anti-anginal action, cardiotonic action or coronary vasodilation, thus being useful as therapeutic or prophylactic agents for the cardiovascular diseases such as hypertension and angina pectoris.

REFERENCES:
patent: 4745124 (1988-05-01), Ryan et al.
Ignarro et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 218, (1981), pp. 739-749.

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