Nitroso-urea derivatives

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 4, 536 18, 536 53, 536 54, 536 55, A61K 3170, C07H 1504

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active

042737664

ABSTRACT:
The present invention relates to new nitroso-urea derivatives, particularly to N.sub.1 -glucofuranosid-6-yl-N.sub.3 -nitroso-ureas, of the general formula I ##STR1## wherein anyone of R.sub.1, R.sub.2, R.sub.3 and R.sub.5 represent hydrogen, optionally substituted alkyl, aralkyl or acyl, or R.sub.1 and R.sub.2 together or R.sub.3 and R.sub.5 together also represent alkylidene or cycloalkylidene, and R.sub.6 represents optionally substituted alkyl; and to processes for producing them.

REFERENCES:
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patent: 4057684 (1977-11-01), Kimura et al.
patent: 4086415 (1978-04-01), Suami et al.
Machinami, T. et al., Bull. Chem. Soc. Japan, 48, 1975 (3761-3762).
Machinami, T. et al., Bull. Chem. Soc. Japan, 46, 1973 (1013-1014).
MOntero, J., et al., C. R. Acad. Sc. Paris, 277, 809-C, 1974.
Bannister, B., J. Antibiotics, 25, 1972 (377-386).

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