Nitrosated and/or nitrosylated cyclooxygenase-2 selective...

Details Nitrosated and/or nitrosylated cyclooxygenase-2 selective... Nitrosated and/or nitrosylated cyclooxygenase-2 selective...

2007-05-22

2007-05-22

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S470000, C514S539000, C544S391000, C549S464000, C560S049000

Reexamination Certificate

active

10718060

ABSTRACT:
The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent. The invention also provides novel compositions comprising at least one COX-2 selective inhibitor, that is optionally sitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent.

REFERENCES:
patent: 5621000 (1997-04-01), Arena et al.
patent: 5700947 (1997-12-01), Del Soldato
patent: 5703073 (1997-12-01), Garvey et al.
patent: 5780495 (1998-07-01), Del Soldato
patent: 5844696 (1998-12-01), Masia et al.
patent: 5861426 (1999-01-01), Del Soldato et al.
patent: 6040341 (2000-03-01), Del Soldato et al.
patent: 6043233 (2000-03-01), Garvey et al.
patent: 6046191 (2000-04-01), Hamley et al.
patent: 6048858 (2000-04-01), Garvey et al.
patent: 6051588 (2000-04-01), Garvey et al.
patent: 6057347 (2000-05-01), Garvey et al.
patent: 6083515 (2000-07-01), Garvey et al.
patent: 6143734 (2000-11-01), Garvey et al.
patent: 6242432 (2001-06-01), Del soldato
patent: 6248745 (2001-06-01), Hamley et al.
patent: 6291523 (2001-09-01), Fujimoto et al.
patent: 6297260 (2001-10-01), Bandarage et al.
patent: 6323234 (2001-11-01), Garvey et al.
patent: 6355680 (2002-03-01), Cohen
patent: 6369260 (2002-04-01), Sannicolo et al.
patent: 6410791 (2002-06-01), Del Soldato
patent: 6482846 (2002-11-01), Garvey et al.
patent: 6512137 (2003-01-01), Del Soldato et al.
patent: 6573252 (2003-06-01), Del Soldato
patent: 6593339 (2003-07-01), Eek
patent: 6593347 (2003-07-01), Bandarage et al.
patent: 6613784 (2003-09-01), Benedini et al.
patent: 0 904 110 (2002-07-01), None
patent: WO 94/04484 (1994-03-01), None
patent: WO 94/12463 (1994-06-01), None
patent: WO 95/09831 (1995-04-01), None
patent: WO 95/30641 (1995-11-01), None
patent: WO 96/32946 (1996-10-01), None
patent: WO 97/16405 (1997-05-01), None
patent: WO 97/31654 (1997-09-01), None
patent: WO 98/09948 (1998-03-01), None
patent: WO 99/11605 (1999-03-01), None
patent: WO 99/44595 (1999-09-01), None
patent: WO 00/00200 (2000-01-01), None
patent: WO 00/06585 (2000-02-01), None
patent: WO 00/25776 (2000-05-01), None
patent: WO 00/44705 (2000-08-01), None
patent: WO 00/51988 (2000-09-01), None
patent: WO 99/45004 (2000-09-01), None
patent: WO 00/61537 (2000-10-01), None
patent: WO 00/61541 (2000-10-01), None
patent: WO 00/61549 (2000-10-01), None
patent: WO 00/61604 (2000-10-01), None
patent: WO 00/72838 (2000-12-01), None
patent: WO 01/00563 (2001-01-01), None
patent: WO 01/04082 (2001-01-01), None
patent: WO 01/10814 (2001-02-01), None
patent: WO 01/12584 (2001-02-01), None
patent: WO 01/23346 (2001-04-01), None
patent: WO 01/45703 (2001-06-01), None
patent: WO 01/56555 (2001-08-01), None
patent: WO 01/87343 (2001-11-01), None
patent: WO 01/93680 (2001-12-01), None
patent: WO 03/000643 (2002-01-01), None
patent: WO 02/11706 (2002-02-01), None
patent: WO 02/11707 (2002-02-01), None
patent: WO 02/20090 (2002-03-01), None
patent: WO 02/30866 (2002-04-01), None
patent: WO 02/051385 (2002-07-01), None
patent: WO 02/053188 (2002-07-01), None
patent: WO 02/092072 (2002-11-01), None
patent: WO 02/100400 (2002-12-01), None
patent: WO 03/000642 (2003-01-01), None
patent: WO 03/013499 (2003-02-01), None
patent: WO 03/033001 (2003-04-01), None
patent: WO 03/049720 (2003-06-01), None
patent: WO 03/084550 (2003-10-01), None
patent: WO 03/094924 (2003-11-01), None
patent: WO 2004/000273 (2003-12-01), None
patent: WO 2004/000300 (2003-12-01), None
patent: WO 2004/000781 (2003-12-01), None
Young, Delano V. et al. “A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods.” Biochemical Pharmacology, 70, pp. 1343-1351. (2005).
Wallace et al., Trends Pharamcol., Sci., 15(11): 405-406 (1994).
Wallace et al., J. Gastroeneterol. Hepatol., 9: S40-S44 (1994).
Wallace et al., Novel Molecualr Approacehs to Anti-inflammatory Theory, 121-129 (1994).
Wallace et al., Gastroeneterol., 106(4), Part 2, A208 (1994) Abstract.
Wallace et al., Eur. J. Pharmacol., 257:249-255 (1994).
Wallace et al., Gastroenterol., 107:173-179 (1994)
Reuter et al., Life Sciences, 55(1):1-8 (1994).
Reuter et al., Gastroenterol., 106 (4), A759 (1994).
Cuzzolin et al, Pharmacol. Res. 29(1): 89-97 (1994).
Rachmilewitz et al., Gut, 35:1394-1397 (1994).
Conforti et al., Agents Action, 40(3): 176-180 (1993).
Carty et al., Agents Actions., 39: 157-165 (1993).
Cuzzolin et al, Pharmacol. Res. 31: 61-65 (1995).
Barrachina et al., Eur. J. Pharmacol., 281: R3-R4 (1995).
MacNaughton et al., Life Sciences, 45: 1869-1876 (1989).
Kitigawa et al., J. Pharamcol. Exp. Therp., 253: 1133-1137 (1990).
Langford et al., Arterioscler. Thromb. Vasc. Biol. 16: 51-57 (1996).
Palmer et al., Nature, 333:664-444 (1998).
Wallace et al., J. Clin. Invest., 96: 2711-2718 (1995).
Konturek et al., Eur. J. Pharmacol., 239:215-217 (1993).
Wallace et al., Expert Opinion Inverstigational Drugs, 4(7):613-619 (1995).
Boughton-Smith et al., Eur. J. Pharmacol., 191:485-488 (1990).
Elliott et al., Gastroenterol., 109: 524-530 (1995).
Wallace et al., Eur. J. Pharmacol., 63-68 (1995).
Brown et al., Eur. J. Pharmacol., 103-104 (1992).
Williams et al., Cancer Research, 61: 3285-3289 (Apr. 15, 2001).
Del Soldato et al., Br. J. Pharmacol., 67:33-37 (1979).
Dec. 15, 2003. International Search Report from PCT/US03/18052.

Affiliated with

Also associated with

Rating

Nitrosated and/or nitrosylated cyclooxygenase-2 selective... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitrosated and/or nitrosylated cyclooxygenase-2 selective..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrosated and/or nitrosylated cyclooxygenase-2 selective... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3777138