Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1996-03-22
1998-10-20
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514178, 514179, 540 63, 540 66, 552572, 552573, 552575, 552565, 552566, A61K 3158, C07J 7100, C07J 700, C07J 500
Patent
active
058246690
ABSTRACT:
Disclosed are (i) compounds of a steroid, a .beta.-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO.sub.2 group or a group which stimulates endogenous production of NO or EDRF in vivo; (ii) compositions of steroids, .beta.-agonists, anticholinergics, mast cell stabilizers and PDE inhibitors, which can optionally be substituted with at least one NO or NO.sub.2 moiety or a group which stimulates endogenous production of NO or EDRF in vivo, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.circle-solid.) or that stimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them in preventing and/or treating respiratory disorders.
REFERENCES:
patent: 3639434 (1972-02-01), Oxley et al.
patent: 3743741 (1973-07-01), Laurent et al.
patent: 3839369 (1974-10-01), Hofmeister et al.
patent: 5707984 (1998-01-01), Tjoeng et al.
Garvey David S.
Letts L. Gordon
Renfroe H. Burt
Richardson Stewart K.
NitroMed Inc.
Rotman Alan L.
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