Nitrosated and nitrosylated .alpha.-adrenergic receptor antagoni

Details Nitrosated and nitrosylated .alpha.-adrenergic receptor antagoni Nitrosated and nitrosylated .alpha.-adrenergic receptor antagoni

1996-02-02

1999-08-03

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514258, 514259, 514260, 514280, 514423, 514562, 514644, 514645, 514 8, 514 23, A01N 4354, A61K 31505, A61K 3113

Patent

active

059325380

ABSTRACT:
Disclosed are nitrosated and nitrosylated .alpha.-adrenergic receptor antagonists, compositions of an .alpha.-adrenergic receptor antagonist (.alpha.-antagonist), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.circle-solid.); and uses for each of them in treating human male impotence or erectile dysfunction.

REFERENCES:
patent: 5236904 (1993-08-01), Gerstenberg et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5447912 (1995-09-01), Gerstenberg et al.
patent: 5474535 (1995-12-01), Place et al.
patent: 5565466 (1996-10-01), Gioco et al.
patent: 5567706 (1996-10-01), Gavras
patent: 5574068 (1996-11-01), Stamler et al.
patent: 5593876 (1997-01-01), Stamler et al.
patent: 5612314 (1997-03-01), Stamler et al.
patent: 5646181 (1997-07-01), Fung et al.
patent: 5648393 (1997-07-01), Stamler et al.
Miyamoto et al, Arzneim-Forsh Drug/Res 41(II) No. 12 (1991) pp. 1216-1221.
Gould et al, Angiology, 32(9):595-600 (1981).
Krane et al, New England Journal Of Medicine, 321(24):1648-1659 (1989).

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