Nitroquinolone derivatives

Details Nitroquinolone derivatives Nitroquinolone derivatives

1993-01-07

1994-12-27

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546155, 546156, 546157, C07D40104, C07D40106, C07D21518, C07D215227

Patent

active

053767489

ABSTRACT:
A class of optionally 4-substituted 3-nitro-2-oxo-1,2,3,4-tetrahydroquinoline derivatives are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.

REFERENCES:
patent: 3962445 (1976-06-01), Buckle et al.
patent: 4192876 (1980-03-01), Hardtmann
patent: 4710507 (1987-12-01), Campbell et al.
Carling, Robert W. et al, "3-Nitro-3,4-Dihydro . . . ", J of Medicinal Chemistry, (as yet to be published-due to be published Sep. 1993).
Dingledine, R. et al, "Excitatory Amino . . . ", TiPS, vol. 11, pp. 334-338, Aug. 1990.

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