Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-10-03
2006-10-03
Richter, Johann (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S246000, C564S265000, C564S266000
Reexamination Certificate
active
07115666
ABSTRACT:
Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therapeutics for inflammation-related conditions and analgesia in mammals, such as arthritis, and for neuropathic pain and traumatic injuries such as traumatic brain injury and acute spinal cord injury.
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Naito et al., The Dipolar 1,3-Cycloaddition of C,N-dialkylnitrone to Olefins with Hydroxyl Group and the Derivatives, Recueil des Travaux Chimiques des Pays-Bas, 1996, 115 (1), 13-19.
Coates et al., Preparation of Vicinal N-Alkylamino Alcohols via Acylation-Rearrangement of Nitrones Followed by Hydride Reduction, J. Org. Chem. 1986, 51, 1383-1389.
Khan M. Amin
Upasani Ravindra B.
Wood Paul L.
Klauber & Jackson
Nwaonicha Chukwuma
Renovis, Inc.
Richter Johann
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