Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1977-09-08
1979-04-24
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548336, A61K 31415, C07D23364
Patent
active
041512898
ABSTRACT:
The compunds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
REFERENCES:
patent: 3917626 (1975-11-01), Edwards
patent: 3932443 (1976-01-01), White
patent: 3969354 (1976-07-01), Tieman et al.
patent: 4038408 (1977-07-01), Durant et al.
patent: 4046906 (1977-09-01), Durant et al.
Conant et al., The Chemistry of Organic Compounds, N.Y., Macmillan, 1939, p. 264.
Brown et al., Chem. Absts., 1973, vol. 78, No. 42874d.
Durant Graham J.
Ganellin Charon R.
Edgerton William H.
Foggio Richard D.
Harkaway Natalia
Keps Joan S.
Smith Kline & French Laboratories Limited
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