Nitromethyl ketones, process for preparing them and compositions

Details Nitromethyl ketones, process for preparing them and compositions Nitromethyl ketones, process for preparing them and compositions

1999-02-25

2000-03-28

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514646, 514677, 514641, 514621, 514616, 514619, 514638, A61K 3104

Patent

active

060432810

ABSTRACT:
The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.

REFERENCES:
patent: 3983156 (1976-09-01), Buckle et al.
patent: 3984565 (1976-10-01), Buckle et al.
patent: 4117137 (1978-09-01), Hardtmann
patent: 4381304 (1983-04-01), Palameta
patent: 4382088 (1983-05-01), Palameta
patent: 5153227 (1992-10-01), Brown
patent: 5360822 (1994-11-01), Morino
patent: 5409933 (1995-04-01), Kim et al.
CA:83:108153 by Buckle in J Med Chem 18 (7) p. 733-6, 1975.
CA:119:43324 abs JP05043518, Feb. 1993.

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