Nitroimidazolyl-triazolo-pyridazine compounds

Details Nitroimidazolyl-triazolo-pyridazine compounds Nitroimidazolyl-triazolo-pyridazine compounds

1975-07-31

1977-02-01

Gallagher, R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260250A, 424250, C07D48704

Patent

active

040061418

ABSTRACT:
Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;
A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or
A is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; and
R.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;
n is 0 or 1;
And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

REFERENCES:
patent: 3928349 (1975-12-01), Berger et al.
Berger et al., Chem. Abs. 81, 63681r (1974).
Berger et al., Chem. Abs. 81, 120673r (1974).

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