Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-04-21
1984-07-31
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548338, 548339, A61K 31415, C07D23394
Patent
active
044630123
ABSTRACT:
The nitroimidazoles having general formula: ##STR1## wherein R represents alkyl C.sub.1 -C.sub.5, hydroxyalkyl C.sub.1 -C.sub.5, an alkylsulfonyl group, an aminoalkyl group, wherein the alkyl contains 1 to 5 carbon atoms and the amino group is the radical of a secondary or tertiary, linear or cyclic amine; R.sub.1 is --OH and R.sub.2 represents the group: ##STR2## the tert-butyl substituent --C(CH.sub.3) being in the 3, 4 or 6 position of the anisole ring or R.sub.1 and R.sub.2 both represent the above indicated group (II), are endowed with activity against pathogenic protozoa and bacteria, particularly as regards Trichomonas vaginalis.
The subject compounds are prepared by reacting a halo-magnesium derivative of tert-butyl-4-hydroxy-anisole and 5-nitro, 1-R substituted, 2-formyl-imidazole.
REFERENCES:
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 684-687.
Chemical Abstracts, 63: 18097b (1965), [Neth. Appl. 6,413,814, 5/28/65.]
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