Nitroimidazoles and compositions thereof

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424246, 424250, 424267, 544 585, 544139, 544370, 546210, 548336, 548339, 2602455, C07D41306, C07D23391, A61K 31535, A61K 31415

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active

042410606

ABSTRACT:
Nitroimidazoles of the formula ##STR1## wherein R.sup.1 and R.sup.2 are as hereinafter set forth, are described. The nitroimidazoles are useful as hypoxic-cell radiosensitizers, as well as being useful as antiprotozoal agents.

REFERENCES:
patent: 3646057 (1972-02-01), Beaman et al.
patent: 4038410 (1977-07-01), Rufer et al.
Adams et al., "Radiation Research", v. 67, (1976), pp. 9-20.
Chapman et al., "Cancer", v. 40, (1977), pp. 484-488.
Brown et al., "Br. J. Cancer", vol. 37, Suppl. III, 1978, pp. 206-211.
Rauth et al., "British J. Cancer", (1978), 37, Suppl. III, pp. 202-205.
Brown, "British J. Cancer", (1978), 38, Suppl. III, pp. 206-211.

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