Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-08-03
1980-12-23
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424246, 424250, 424267, 544 585, 544139, 544370, 546210, 548336, 548339, 2602455, C07D41306, C07D23391, A61K 31535, A61K 31415
Patent
active
042410606
ABSTRACT:
Nitroimidazoles of the formula ##STR1## wherein R.sup.1 and R.sup.2 are as hereinafter set forth, are described. The nitroimidazoles are useful as hypoxic-cell radiosensitizers, as well as being useful as antiprotozoal agents.
REFERENCES:
patent: 3646057 (1972-02-01), Beaman et al.
patent: 4038410 (1977-07-01), Rufer et al.
Adams et al., "Radiation Research", v. 67, (1976), pp. 9-20.
Chapman et al., "Cancer", v. 40, (1977), pp. 484-488.
Brown et al., "Br. J. Cancer", vol. 37, Suppl. III, 1978, pp. 206-211.
Rauth et al., "British J. Cancer", (1978), 37, Suppl. III, pp. 202-205.
Brown, "British J. Cancer", (1978), 38, Suppl. III, pp. 206-211.
Gould George M.
Hoffmann-La Roche Inc.
Jiles Henry R.
Ramsuer R. W.
Saxe Jon S.
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