Nitroimidazole derivatives and process for the preparation there

Details Nitroimidazole derivatives and process for the preparation there Nitroimidazole derivatives and process for the preparation there

1975-03-12

1977-07-26

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602564N, 2602564R, 260309, 2603096, 260310R, 260307H, 424251, A61K 922, C07D23922, C07D40304

Patent

active

040384101

ABSTRACT:
Nitroimidazoles of the formula ##STR1## wherein R is dialkylaminoacryloyl; 3-, 4-, or 5-pyrazolyl or a mixture thereof which is unsubstituted or substituted by alkyl or, at the 1-position, by hydroxyalkyl or a nitro ester thereof, acyloxyalkyl, nitro, phenyl or phenyl p-substituted by halo, alkoxy or nitro, or, in the 3- or 5-position or a mixture thereof by nitro; 3- or 5-alkyl-4-isooxazolyl or a mixture thereof; or 4-alkyl-5-pyrimidinyl, unsubstituted or substituted by alkyl, amino, 2-furyl or 5-nitro-2-furyl, and the physiologically acceptable acid addition salts thereof, possess anti-protozoal activity, e.g., against trichomonas vaginalis and Entamoeba histolytica.

REFERENCES:
patent: 3798232 (1974-03-01), Wittekind et al.
patent: 3883549 (1975-05-01), Pearson

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