Nitroglycerine plaster and process for its production

Details Nitroglycerine plaster and process for its production Nitroglycerine plaster and process for its production

1994-03-14

1996-03-12

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1300

Patent

active

054984181

DESCRIPTION:

BRIEF SUMMARY
This application is a 371 of PCT/EP92/01169 filed May 25, 1992. The invention relates to a dermal plaster for the transdermal administration of nitroglycerine, comprising a carrier film and a nitrogylcerine-containing adhesive body on the basis of a crosslinked acrylate copolymer. The plaster also has a protective film which is removed by pulling off prior to the use of the plaster--i.e., prior to its application to the skin.
Many dermal plasters for the transdermal administration of nitroglycerine are known. For example, DE 2135533 and DE 3315272 disclose plasters which are built up from a number of layers and control the delivery of the active agent. Nitroglycerine is released by different mechanisms, either from a single-layer reservoir via a control membrane (DE 2135533), or by a particular design of the multi-layer reservoir (DE 3315272). Since multilayer dermal plasters are very expensive, more particularly to manufacture, in the recent past plasters have been developed which consist of a single layer in addition to the carrier film. In order to enable sufficient nitroglycerine to be absorbed and again adequately delivered to the skin, various self-adhesive adhesive substances have been developed with the most various properties as regards absorptivity of active agent, delivery of active agent and adhesive properties to the skin. As examples, the following may be mentioned: GB A 2095108, DE OS 3231400, GB A 2086224, EP A 0062682, EP 85903926.5, EP 86902978.5, EP 0285550, EP 0272562, US 4608249 and DE PS 3200369. In dependence on the materials used and the degree of crosslinkage, the plasters have different absorptive capacity and delivery capacity for nitroglycerine and are characterized by varying adhesive capacity to the skin. Varying skin compatibility also plays a considerable role. Many plasters also contain substances for increasing the transepidermal transport of substances (so-called resorption accelerators).
It is an object of the invention to provide a dermal plaster for the transdermal administration of nitroglycerine which is characterized by the use of an adhesive which has not only as high an absorptive capacity as possible, but also a high delivery capacity for nitroglycerine, so that the release surface of the plaster can be small with the necessary quantity released per day, and therefore the cost of the plaster is as low as possible. At the same time, the use of a special adhesive simplifies the production process, makes it inexpensive and economizes on the addition of resorption accelerators. This simplification of the pharmaceutical formulation at the same time reduces the risk of skin irritations and/or of any uncontrollable change in the nitroglycerine concentration in the adhesive body, something which may accompany the penetration of resorption accelerators from the adhesive into the skin.
The dermal plaster according to the invention for the transdermal administration of nitroglycerine, comprising a carrier foil, a nitroglycerine-containing adhesive on the basis of a crosslinked acrylate-vinyl acetate copolymer, and a conventional removable protective film is characterized in that the nitroglycerine-containing adhesive substance is obtained by the radical polymerization in a first stage of a mixture consisting of 21 to 40% by weight vinyl acetate, 55 to 70% by weight of an acrylic acid-C.sub.2-8 -alkyl ester and 3 to 10% by weight of an acrylic acid-C.sub.2-4 -hydroxyl acryl ester, with 100% by weight monomers in the mixture, in an organic solvent, whereafter in a second stage a conventional crosslinkage agent in an organic solvent and the nitroglycerine in the quantity required for the intended use of the plaster is admixed, if necessary in an organic solvent, and finally in a third stage the resulting mixture or the particular acrylate-vinyl acetate copolymer is crosslinked in an additional stage, accompanied by heating and the removal of the organic solvent or mixture of solvents used, and the resulting nitroglycerine is "built into" the adhesive substance in a special man

REFERENCES:
patent: 4994267 (1991-02-01), Sablotsky
Chemical Abstracts, vol. 97, No. 12, Sep. 1982, Abstract No. 98386f.

Affiliated with

Also associated with

Rating

Nitroglycerine plaster and process for its production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitroglycerine plaster and process for its production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitroglycerine plaster and process for its production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2098694