Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-01
2005-11-01
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252110, C514S253020, C514S253060, C544S058200, C544S061000, C544S121000, C544S357000, C544S363000
Reexamination Certificate
active
06960580
ABSTRACT:
The present invention relates to nitrogen-containing heterocyclic quinoline compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. More particularly, the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
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Agrawal, Vijal K., et al., “Antiparasitic agents. Part VI. Synthesis of 7-chloro-4-(4-substituted-phenylamino)- and 7-chloro-4-(4-substituted-piperazin-1-yl)quinolines as potential antiparasitic agents”, Indian J. Chem., Sect. B, 1987, 26B(6), 550-5.
Pandey Anjali
Scarborough Robert M.
Kifle Bruck
Millennium Pharmaceuticals Inc.
Townsend and Townsend / and Crew LLP
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