Nitrogenous heterocyclic derivatives, medicinal compositions...

Details Nitrogenous heterocyclic derivatives, medicinal compositions... Nitrogenous heterocyclic derivatives, medicinal compositions...

2007-09-18

2007-09-18

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S866000, C514S909000, C536S004100, C536S018100

Reexamination Certificate

active

10481013

ABSTRACT:
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula:wherein X1and X3independently represent N or CH; X2represents N or CR2; X4represents N or CR3; and with the proviso that one or two of X1, X2, X3and X4represent N; R1represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkoxy-substituted (lower alkyl) group, a lower alkoxy-substituted (lower alkoxy) group, a lower alkoxy(lower alkoxy)-substituted (lower alkyl) group, a cyclic lower alkyl group, a halo(lower alkyl) group or a group represented by the general formula: HO-A- wherein A represents a lower alkylene group, a lower alkyleneoxy group or a lower alkylenethio group; R2represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyclic lower alkyl group, a lower alkoxy group, an amino group, a (lower acyl)amino group, a mono(lower alkyl)amino group or a di(lower alkyl)amino group; and R3represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, or prodrugs thereof which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutical compositions comprising the same, and pharmaceutical uses and production intermediates thereof.

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