Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-05-20
2008-05-20
Seaman, Margaret D. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S415000, C546S119000, C548S361100
Reexamination Certificate
active
10591757
ABSTRACT:
The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula R1represent H, an optionally substituted alkyl group, analkenyl group, etc.; R2represent H, a halogen atom or an alkyl group; R3and R4represent H, OH, a halogen atom, an optionally substituted alkyl group, etc.; Y represents CH or N; Q represents alkylene, alkenylene, etc.; ring A represents an aryl group or a heteroaryl group; G represents a group represented by the following general formula (G-1) or (G-2) (in which E1represents H, F or OH; and E2represents H, F, a methyl group, etc.), and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof
REFERENCES:
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patent: 2003-12686 (2003-01-01), None
patent: WO 2004/087727 (2004-10-01), None
patent: WO 2004/113359 (2004-12-01), None
Majowicz et al., Peptides, 2003, vol. 24, pp. 1971-1976.
Ohsumi, K. et al.; Pyrazole-o-Glucosides as Novel Na=-Glucose Cotransporter (SGLT) Inhibitors. Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13, pp. 2269 to 2272.
Fushimi Nobuhiko
Isaji Masayuki
Ito Fumiaki
Shimizu Kazuo
Teranishi Hirotaka
Kissei Pharmaceutical Co. Ltd.
Rahmani Niloofar
Seaman Margaret D.
Sughrue & Mion, PLLC
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