Nitrogenous 5-membered ring compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S372000

Reexamination Certificate

active

07138397

ABSTRACT:
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:wherein symbols in the formula have the following meanings;A: —CH2— or —S—,B: CH or N,R1: H, a lower alkyl group, etc.,X: a single bonding arm, —CO—, -Alk-CO—, —COCH2—, -Alk-O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, -Alk-CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc.,R3: hydrogen atom or a lower alkyl group,Alk: a lower alkylene group, andR2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 6011155 (2000-01-01), Villhauer
patent: 6107317 (2000-08-01), Villhauer
patent: 6110949 (2000-08-01), Villhauer
patent: 6432969 (2002-08-01), Villhauer
patent: WO 98/19998 (1998-05-01), None
patent: WO 00/34241 (2000-06-01), None
patent: WO 01/96295 (2001-12-01), None
patent: WO 02/051836 (2002-07-01), None
Augustyns, K., et al., The Unique Properties of Dipeptidyl-peptidase IV (DPP IV / CD 26) and the Therapeutic Potential of DPP IV Inhibitors,Current Medicinal Chemistry, pp. 311-327 (1999).
Supplementary European Search Report for related application EP 01 97 4716, mailed Apr. 6, 2005.

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