Nitrogen—containing heterocyclic derivatives having...

Details Nitrogen—containing heterocyclic derivatives having... Nitrogen—containing heterocyclic derivatives having...

2004-03-05

2011-10-25

Desai, Rita J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S317000

Reexamination Certificate

active

08044206

ABSTRACT:
The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.

REFERENCES:
patent: 3658797 (1972-04-01), Ross et al.
patent: 4514412 (1985-04-01), Karjalainen et al.
patent: 4639452 (1987-01-01), Platel et al.
patent: 6784192 (2004-08-01), Ozaki et al.
patent: 2003/0220368 (2003-11-01), Ozaki et al.
patent: 2004/0167224 (2004-08-01), Ozaki et al.
patent: 2004/0172543 (2004-09-01), Sato et al.
patent: 2008/0070898 (2008-03-01), Kikuchi et al.
patent: 34473 (1981-08-01), None
patent: 0 072 615 (1983-02-01), None
patent: 0 279 681 (1988-02-01), None
patent: 551617 (1993-07-01), None
patent: 0909564 (1999-04-01), None
patent: 1180513 (2002-02-01), None
patent: 1 254 904 (2002-11-01), None
patent: 1422782 (2004-05-01), None
patent: 1602645 (2005-12-01), None
patent: 58-159484 (1983-09-01), None
patent: 60-193966 (1985-10-01), None
patent: 1-316359 (1989-12-01), None
patent: 2-179 (1990-01-01), None
patent: 4-342579 (1992-11-01), None
patent: 4-342579 (1992-11-01), None
patent: 5-213915 (1993-08-01), None
patent: 2001-270883 (2001-10-01), None
patent: 2002-523448 (2002-07-01), None
patent: WO 91/18603 (1991-12-01), None
patent: WO 93/12110 (1993-06-01), None
patent: 94/13291 (1994-06-01), None
patent: WO 95/24390 (1995-09-01), None
patent: WO 96/13479 (1996-05-01), None
patent: WO 97/19059 (1997-05-01), None
patent: 99/02497 (1999-01-01), None
patent: WO 99/02497 (1999-01-01), None
patent: WO 99/08678 (1999-02-01), None
patent: 00/12074 (2000-03-01), None
patent: WO 01/07436 (2001-02-01), None
patent: WO 01/16121 (2001-03-01), None
patent: 01/53288 (2001-07-01), None
patent: WO 01/53288 (2001-07-01), None
patent: WO 01/74796 (2001-10-01), None
patent: WO 02/46166 (2002-06-01), None
patent: 02/066484 (2002-08-01), None
patent: WO 02/102381 (2002-12-01), None
patent: WO 2004/011430 (2004-02-01), None
patent: WO 2004/011430 (2004-02-01), None
patent: WO 2004/037817 (2004-05-01), None
patent: 2004/078715 (2004-09-01), None
Benedetti, P. et al J. Med. Chem. 2002, 45, 1577-1584.
Carl Tabb Banner, et al, “4-(4-Dimethylaminostyryl)quinolines with a methyl group on the styryl ring,” Journal of Organic Chemistry, vol. 26, No. 7, pp. 2566-2567, 1961.
S.K. Chervenkov, et al, “IR-,1H-NMR and TLC examination of new 2-styrylquinolines with antibacterial activity,” Analytical Letters, vol. 28, No. 1, pp. 59-70, 1995.
A. Haddow, et al, “Investigations of tumour-inhibitory styrylquinoline derivatives,” Acta Unio Internationalis Contra Cancrum, vol. 16, pp. 489-495, 1960.
John A. Lamberton, et al, “Alkaloids of Peripentadenia mearsii. I. Isolation, Structural Determination, and Synthesis of Peripentadenine,” Journal of Natural Products, vol. 46, No. 2, pp. 235-247, 1983.
S. V. Tsukerman, et al, “Synthesis of chalcone analogs from 2-acetylquinoline,” Zhurnal Obshchei Khimii, vol. 34, No. 9, pp. 2881-2886, 1964 Abstract.
Supplementary European Search Report dated Nov. 5, 2008.
Yinglin Han, et al., “Total Asymmetric Synthesis of Highly Constrained Amino Acids β-Isopropyl-2′,6′ -Dimethyl-Tyrosines,”Tetrahedron Letters, vol. 38, No. 29, pp. 5135-5138, 1997.
Ryszard Gawinecki, et al., “The effect of the amino group on the spectral properties of substituted styrylpyridinium salts,”Dyes and Pigments, vol. 45, pp. 103-107, 2000.
Beata Jedrzejewska, et al., “Hemicyanine dyes: synthesis, structure and photophysical properties,”Dyes and Pigments, vol. 58, pp. 47-58, 2003.
Vladimir V. Rozhkov, et al., “Synthesis of 2-Aryl- and 2-Hetaryl-4, 6-dinitroindols from 2, 4, 6-Trinitrotoluene,” Synthesis, 1999, No. 12, pp. 2065-2070.
C.T. Bahner, et al., “Di- and Tri-methoxystyryl Derivatives of Heterocyclic Nitrogen Compounds,”Arzneimittel-Forschung, 1981, vol. 31, No. 3, pp. 404-406.
Office Action issued on Oct. 5, 2010 from the European Patent Office in a counterpart European Application No. 04717835.5.
Cignabella G. et al., “Bicyclic Homologs of Piperazine. VII.1 Synthesis and Analgesic Activity of 3-Aralkenyl-8-propionyl-3,8-diazabicyclo[3.2.1]-octanes”, J. Med. Chem. 1965, vol. 8, pp. 326-331.
Japanese Office Action issued on Jul. 5, 2010 from the Japan Patent Office in a counterpart Japanese application No. 2005-503134.
Chinese Office Action issued in CN 2005800293270, dated Jan. 8, 2010.
M. Lamontagne et al., “Antimalarials. 8. Synthesis of Amino Ethers as Candidate Antimalarials,” Journal of Medicinal Chemistry, vol. 19, No. 3, pp. 360-365, 1976.
Kikuchi et al “Preparation of nitrogenous . . . ” CA141:260786 (2004).
Communication dated Mar. 8, 2011 from the European Patent Office in a counterpart European application (EP 04717835.5).

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