Nitrogen substituted acridine and cytochrome P450 inhibitors and

Details Nitrogen substituted acridine and cytochrome P450 inhibitors and Nitrogen substituted acridine and cytochrome P450 inhibitors and

1992-09-10

1995-06-06

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514297, 514400, A61K 3144

Patent

active

054223504

ABSTRACT:
Described is a method of inhibiting the enzymatic metabolism of nitrogen substituted acridines of Formula 1 comprising co-administering with the acridine an effective oxidase inhibiting amount of a P450 1A2 inhibitor. The oxidase is one whose activity is induced by beta-naphthaflavone, 3-methylcholanthrene, arochlor, 2,3,7,8-tetrachlorodibenzo-p-dioxin and isosafrole. The oxidase inhibitor may be a naphthyridine, a xanthine, a phenoxy amino alkane, a carbamoyl imidazole, a heterocyclic guanidine, or a quinoline.

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