Drug – bio-affecting and body treating compositions – Designated inorganic nonactive ingredient or elemental... – Siliceous or calcareous material
Patent
1998-01-05
2000-04-18
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated inorganic nonactive ingredient or elemental...
Siliceous or calcareous material
514789, 514921, 428520, 428529, 428548, 428553, 428557, 428558, 428559, 428563, 428568, 428570, 428571, 428572, 428573, 428574, A61K 3512, A61K 3536
Patent
active
060516135
ABSTRACT:
A pharmaceutical composition containing an extract from inflammatory tissue inoculated with vaccinia virus may be used to suppress the death of cells caused by endotoxin, and suppress excessive production of nitrogen monoxide induced by endotoxin. The extract may also be used to relieve hypotension induced by endotoxin. In sepsis and other serious bacterial infectious diseases, endotoxin (an intracellular toxin) is produced and a shock symptom is induced by its action. The extract, having an excellent inhibitory action toward endotoxin-induced toxicity, is quite useful for the treatment or the prevention of endotoxin-induced shock symptoms, sepsis and various symptoms accompanied thereby. In addition, the extract has an inhibitory action towards abnormal nitrogen monoxide production during the diseased state and, therefore, it is also useful as a therapeutic and preventive agent for diseases wherein an excessive nitrogen monoxide production occurs, such as acute hypotension.
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Yokoi, et al., "Effect of Degree of Polymerization of Silicic Acid on the Gastrointestinal Absorption of Silicates in Rats", Chem. Pharm. Bull., vol. 27, No. 8, 1979, pp. 1733-1739.
Konishi Jin-emon
Ohno Kousaku
Suehiro Seishi
Krass Frederick
Nippon Zoki Pharmaceutical Co. Ltd.
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