Nitrogen-containing polycyclic compounds and a process for the p

Details Nitrogen-containing polycyclic compounds and a process for the p Nitrogen-containing polycyclic compounds and a process for the p

1975-09-17

1977-10-18

Jaisle, Cecilia M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260296P, C07D47104

Patent

active

040545717

ABSTRACT:
The invention relates to new eburnamenine derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for an alkyl group,
R.sub.2 stands for a carboxy group, a functional carboxy derivative (preferably an ester group) or a group convertable into carboxy group or a functional derivative thereof (preferably cyano group), and
X.sup.- is an anion derived from an acid,
And the corresponding free bases.
These compounds are valuable intermediates of the preparation of eburnamenine derivatives with advantageous therapeutical effects.
The above compounds are prepared as follows: a compound of the general formula (II), ##STR2## wherein R.sub.1 has the same meanings as defined above, is reacted with a compound of the general formula (III), ##STR3## wherein R.sub.2 has the same meanings as defined above and Y is halogen, and, if desired, a thus-obtained compound of the general formula (I), wherein R.sub.1 and R.sub.2 each have the same meanings as defined above and X.sup.- is a halide ion, is reacted with an acid, and/or, if desired, a compound of the general formula (I), wherein R.sub.1 and X.sup.- each have the same meanings as defined above and R.sub.2 is cyano or an ester group, is subjected to hydrolysis, and/or, if desired, a compound of the general formula (I), wherein R.sub.1, R.sub.2 and X.sup.- each have the same meanings as defined above, is treated with a base.

REFERENCES:
wieland, et al., C.A. vol. 51: 7370-7372 (1957).

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