Nitrogen-containing polycyclic compounds

Details Nitrogen-containing polycyclic compounds Nitrogen-containing polycyclic compounds

1975-09-17

1977-11-08

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029353, 2602949, 424267, C07D47102, C07D45502

Patent

active

040575500

ABSTRACT:
New compounds of the general formula (I) ##STR1## wherein R.sub.1 stands for alkyl and R.sub.2 stands for carboxy, a functional carboxy derivative or a group convertible into carboxy group or a functional derivative thereof, have been prepared by reducing a compound of the general formula ##STR2## wherein R.sub.1 and R.sub.2 each have the same meanings as defined above and X.sup.- represents an anion derived from an acid, and optionally subjecting the obtained compound to hydrolysis. If desired, the racemic compounds of the general formula (I) can be resolved to yield the corresponding optically active isomers. The free bases of the general formula (I) can be converted into their pharmaceutically acceptable salts, or the salts can be treated with an alkaline agent to yield the free bases.
The compounds of the general formula (I) can be used in the therapy primarily as vasodilatating agents.

REFERENCES:
patent: 3454583 (1969-07-01), Kuehne
patent: 3925392 (1975-12-01), Najer et al.
Blaha et al., Coll. Czech. Chem. Comm. 33, 3833-3847 (1968).
Bartlett et al., J. Org. Chem. 28, 2197-2199 (1963).

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