Nitrogen-containing oxyalkylene esters and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514356, 514535, 514536, 514547, 546318, 560 19, 560170, A01N 3712, A01N 4340, A01N 3702, C07C22952

Patent

active

061109703

ABSTRACT:
This invention relates to nitrogen-containing oxyalkylene diester compositions for treating disease conditions including cancer and other proliferative diseases. The nitrogen-containing oxyalkylene diesters are represented by the formula ##STR1## where the nitrogen-containing group is R.sub.3 and includes particular alkyl, alkenyl, cycloalkyl, aryl, aralkyl, heterocycloalkyl or heteroaryl groups, which have nitrogen-containing substituents, such as amines, amides, or nitrogen heteroatoms.

REFERENCES:
patent: 2940855 (1960-06-01), Beavers et al.
patent: 3219630 (1965-11-01), Sidi
patent: 3293220 (1966-12-01), Minami et al.
patent: 3336262 (1967-08-01), Sidi
patent: 3720706 (1973-03-01), Lapporte et al.
patent: 3812176 (1974-05-01), Lapporte et al.
patent: 3931412 (1976-01-01), Kensler, Jr. et al.
patent: 4012526 (1977-03-01), Kensler, Jr. et al.
patent: 4105681 (1978-08-01), Bollag et al.
patent: 4123552 (1978-10-01), Kensler, Jr. et al.
patent: 4198416 (1980-04-01), Koeda et al.
patent: 4215215 (1980-07-01), Bollag et al.
patent: 4541944 (1985-09-01), Sanderson
patent: 4545784 (1985-10-01), Sanderson
patent: 4613505 (1986-09-01), Mizushima et al.
patent: 4699925 (1987-10-01), Uchida et al.
patent: 4760057 (1988-07-01), Alexander
patent: 4885311 (1989-12-01), Parish et al.
patent: 4900478 (1990-02-01), Gross
patent: 4916230 (1990-04-01), Alexander
patent: 5025029 (1991-06-01), Perrine
patent: 5158773 (1992-10-01), Gross
patent: 5185436 (1993-02-01), Villa et al.
patent: 5196567 (1993-03-01), Uchida et al.
patent: 5200553 (1993-04-01), Nudelman et al.
patent: 5216004 (1993-06-01), Perrine
patent: 5569675 (1996-10-01), Rephaeli et al.
patent: 5710176 (1998-01-01), Rephaeli et al.
Database CAPLUS on STN, Acc. No. 1988:528504, Thorat et al., `Polymer-supported reagents: synthesis to hippuric acid esters using anion exchange resin.` Indian J. Chem. Sect. B (1987), 26B(9), p809-810, abstract, 1987.
Brant and Conklin, "Acrolein Diacylates", Chem. Abstracts, vol. 40, p. 3127, 1946.
Carstea, et al., "Analogues of Butyric Acid that Increase the Expression of Transfected DNAs", Biochem. Biophys. Res. Com., vol. 192, No. 2, pp. 649-656, 1993.
Cheng, et al., "Functional Activation of the Cystic Fibrosis Trafficking Mutant deltaF508-CFTR by Overexpression", American Journal of Physiology, vol. 268, No. 4, pp. L615-L624, 1995.
Falch and Krogsgaard-Larsen, "Esters of Isoguvacine as Potential Prodrugs", J. Med. Chem., vol. 24, pp. 285-289, 1981.
Hachisu et al, "Synthesis and Antihypertensive Activity of 5-O-Substituted Derivatives of 5-Hydroxypicolinic Acid", J. Pharm. Dyn., vol. 6, pp. 922-931, 1983.
Ingram and Thomas, "The Electron Impact Induced Fragmentation of Germinal Dialkanoates" Organic Mass Spectrometry, vol. 12, No. 4, pp. 216-221, 1977.
Man, et al., "Boron Fluoride Catalyzed Addition of Aliphatic Anhydrides to Aldehydes", J. Am. Chem. Soc., pp. 847-848, 1950.
Miller, et al., "Clinical Pharmacology of Sodium Butyrate in Patients with Acute Leukemia" Eur. J. Cancer Clin Oncol. vol. 23, No. 9, pp. 1283-1287, 1987.
Mosher and Kehr, "The Oxidation of Aliphatic Esters with Lead Tetraacetate" J. Am. Chem. Soc., vol. 82, pp. 5342-5345, 1960.
Nielsen and Bundgaard, "Evaluation of Glycolamide Esters and Various Other Esters of Aspirin as True Aspirin Prodrugs", J. Medicinal Chem., vol. 32, pp. 727-734, 1989.
Novogrodsky, et al., "Effect of Polar Organic Compounds on Leukemic Cells", Cancer, vol. 51, No. 1, pp. 9-14, 1983.
Nudelman, et al., "Novel Anticancer Prodrugs of Butyric Acid", J. Med. Chem., vol. 35, pp. 687-694, 1992.
Oh, et al., "Convenient Synthesis of Geminal Biscarboxylates: Searching for an Efficient Route to HR 916B", Korean J. Med. Chem., vol. 6, No. 2, pp. 259-262, 1996.
Rephaeli, et al., "Butyrate-Induced Differentiation in Leukemic Myeloid Cells: in vitro and in vivo Studies", International Journal of Oncology, vol. 4, No. 6, pp. 1387-1391, 1994.
Sher et al., "Extended Therapy with Intravenous Arginine Butyrate in Patients with Beta--Hemoglobinopathies", New England Journal of Medicine, vol. 332, No. 24, pp. 1606-1610, 1995.
Smith, et al., "Incorporation of Tributyrin Enhances the Expression of a Reporter Gene in Primary and Immortalized Cell Lines", Biotechniques, vol. 18, pp. 852-855, 1995.
Stamatoyannopoulos, et al. "Therapeutic Approaches to Hemoglobin Switching in Treatment of Hemoglobinopathies", Ann. Rev. Med., vol. 43, pp. 497-522, 1992.
Tang, et al., "Butyrate-Inducible and Tumor-Restricted Gene Expression by Adenovirus Vectors", Cancer Gene Therapy, vol. 1, No. 1, pp. 15-20, 1994.
Tomiska and Spousta, "Low-Molecular Polyoxymethylene Diacetates from Trioxane", Angew. Chem. Internat. Edit., vol. 1, No. 4, p 211, 1962.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nitrogen-containing oxyalkylene esters and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitrogen-containing oxyalkylene esters and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrogen-containing oxyalkylene esters and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1250476

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.