Nitrogen-containing heterocyclic ring derivatives

Details Nitrogen-containing heterocyclic ring derivatives Nitrogen-containing heterocyclic ring derivatives

1979-08-20

1981-08-18

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49804

Patent

active

042847788

ABSTRACT:
Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein one of R.sub.1 and R.sub.2 represents a lower alkyl group, a phenyl group, a halophenyl group, or a lower alkoxyphenyl group and the other of them represents a hydrogen atom, a lower alkyl group, or a phenyl lower alkyl group; said R.sub.1 and R.sub.2 may combine with each other to form a trimethylene group or a tetramethylene group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a phenyl group, or a phenyl lower alkyl group; X represents an oxygen atom, a sulfur atom, an imino group, or a group shown by ##STR2## wherein m represents 1 or 2 and R.sub.4 represents a lower alkyl group, a hydroxy lower alkyl group, a cycloalkyl group or a phenyl lower alkyl group; and Y represents an ethylene group which may be substituted by a lower alkyl group, a trimethylene group, a tetramethylene group, a vinylene group which may be substituted by lower alkyl group, or ##STR3## wherein R.sub.5 represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, or a phenyl group; said X is the group shown by ##STR4## when one of said R.sub.1 and R.sub.2 is a lower alkyl group and the other is a hydrogen atom, and said Y is an ethylene group, and the pharmacologically acceptable non-toxic salts thereof. The compound described above are strong analgesic anti-inflammatory agents.

REFERENCES:
patent: 3334095 (1967-08-01), Houlihan
patent: 4186200 (1980-01-01), Kubo et al.
Aeberli et al., J. Med. Chem. vol. 19, pp. 436-438 (1976).
Kuhn et al., Chem. Ber. vol. 86, pp. 468-472 (1953).
Smissman et al., J. Org. Chem. vol. 37, pp. 1092-1094 (1972).
Geigy-AG, Chem. Abstracts, vol. 64, cols. 3563 to 3564 (1966) (abst. of Belg. Patent 659,529).

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