Nitrogen-containing heterocyclic compounds

Details Nitrogen-containing heterocyclic compounds Nitrogen-containing heterocyclic compounds

1979-08-20

1981-02-17

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546114, A61K 31435, C07D47102

Patent

active

042515335

ABSTRACT:
Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein one of R.sub.1 and R.sub.2 represents a lower alkyl group, a phenyl group, a halophenyl group, or a lower alkoxyphenyl group and the other of them represents a hydrogen atom, a lower alkyl group, or a phenyl lower alkyl group; said R.sub.1 and R.sub.2 may combine with each other to form a trimethylene group or a tetramethylene group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a phenyl group, or a phenyl lower alkyl group; X represents an oxygen atom, a sulfur atom, an imino group, or a group shown by ##STR2## wherein m represents 1 or 2 and R.sub.4 represents a lower alkyl group, a hydroxy lower alkyl group, a cycloalkyl group or a phenyl lower alkyl group; and Y represents an ethylene group which may be substituted by lower alkyl group, a trimethylene group, a tetramethylene group, a vinylene group which may be substituted by a lower alkyl group, or ##STR3## wherein R.sub.5 represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, or a phenyl group; said X is the group shown by ##STR4## when one of said R.sub.1 and R.sub.2 is a lower alkyl group and the other is a hydrogen atom, and said Y is an ethylene group, 1/7
and the pharmacologically acceptable non-toxic salts thereof.
The compounds described above are strong analgesic anti-inflammatory agents.

REFERENCES:
patent: 3334091 (1967-08-01), Houlihan
patent: 3646022 (1972-02-01), Graf et al.
Chem. Abstracts 1947-1956, Collective Index, p. 12588s, Chem. Ber. 86 (1953), pp. 468-472.

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