Nitrogen-containing heteroaryl compounds having HIV...

Details Nitrogen-containing heteroaryl compounds having HIV... Nitrogen-containing heteroaryl compounds having HIV...

2006-12-12

2006-12-12

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S168000, C546S169000, C546S170000

Reexamination Certificate

active

07148237

ABSTRACT:
A compound of the formula (I):wherein Z4, Z5and Z9each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RAis a group of the formula:(wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.

REFERENCES:
patent: 3954733 (1976-05-01), Tobiki et al.
patent: 3992371 (1976-11-01), Tobiki et al.
patent: 4125611 (1978-11-01), Yamade et al.
patent: 5681832 (1997-10-01), Haugwitz et al.
patent: 370082 (1963-08-01), None
patent: 52-27794 (1977-03-01), None
patent: 52-93790 (1977-08-01), None
patent: 5-27385 (1993-02-01), None
patent: 98/11073 (1998-03-01), None
patent: 98/45269 (1998-10-01), None
patent: 02/04443 (2002-01-01), None
patent: 02/30426 (2002-04-01), None
patent: 02/30930 (2002-04-01), None
patent: 02/30931 (2002-04-01), None
patent: 02/36734 (2002-05-01), None
patent: 02/055079 (2002-07-01), None
Schindler et al., CAPLUS Abstract 60:30870, 1963.
Marcus et al., PubMed Abstract (Intervirology 45(4-6):260-6), 2002.
van Heeswijk et al., PubMed Abstract (Antivir Ther. 6(4):201-29), 2001.
M. Quali et al., “Modeling of the Inhibition of Retroviral Integrases by Styrylquinoline Derivatives”, J. Med. Chem., vol. 43, No. 10, pp. 1949-1957, 2000.
F. Zouhiri et al., “Structure-Activity Relationships and Binding Mode of Styrylquinolines as Potent Inhibitors of HIV-1 Integrase and Replication of HIV-1 in Cell Culture”, J. MEd. Chem., vol. 43, No. 8, pp. 1533-1540.
K. Mekouar et al., “Styrylquinoline Derivatives: A New Class of Potent HIV-1 Integrase Inhibitors that Block HIV-1 Replication in Cem Cells”, J. Med. Chem., vol. 41, No. 15, pp. 2846-2857, 1998.
I.S. Haworth et al., “A Prototype Bioreductive DNA groove Binding Ligand”, Anti-Cancer Drug Design, vol. 6, No. 1, pp. 59-70, 1991.
M.S. Shankar et al., “Synthesis of Substituted 6-Pyrazolo and 6-Isoxazolo-Benzoxazoles and Their Physiological Activity”, J. Indian Chem. Society, vol. 59, No. 9, pp. 1104-1105, 1982.
F. Zouhiri et al., “HIV-1 Replication Inhibitors of the Styrylquinoline Class: Incorporation of a Masked Diketo Acid Pharmacophore”, vol. 42, No. 46, pp. 8189-8192, 2001.

Affiliated with

Also associated with

Rating

Nitrogen-containing heteroaryl compounds having HIV... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitrogen-containing heteroaryl compounds having HIV..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrogen-containing heteroaryl compounds having HIV... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3660431