Nitrogen-containing heteroaryl compounds and methods of use...

Details Nitrogen-containing heteroaryl compounds and methods of use... Nitrogen-containing heteroaryl compounds and methods of use...

2008-01-29

2008-01-29

Davis, Zinna N. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S146000

Reexamination Certificate

active

10861082

ABSTRACT:
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.

REFERENCES:
patent: 3989704 (1976-11-01), Houlihan et al.
patent: 4036964 (1977-07-01), Buckle et al.
patent: 4260611 (1981-04-01), Bartmann et al.
patent: 4559403 (1985-12-01), Bruderer et al.
patent: 4584379 (1986-04-01), Wagner
patent: 4673682 (1987-06-01), Konz et al.
patent: 4822800 (1989-04-01), Faltico et al.
patent: 4952588 (1990-08-01), Glamkowski et al.
patent: 4966906 (1990-10-01), Glamkowski et al.
patent: 5620995 (1997-04-01), Weidmann et al.
patent: 5658933 (1997-08-01), Weidmann et al.
patent: 5719164 (1998-02-01), Weidmann et al.
patent: 6093730 (2000-07-01), Weidmann et al.
patent: 6319931 (2001-11-01), Kroemer et al.
patent: 6358973 (2002-03-01), Napoletano et al.
patent: 6358976 (2002-03-01), Wityak et al.
patent: 6369053 (2002-04-01), Yuan et al.
patent: 6762318 (2004-07-01), Kodra et al.
patent: 6777425 (2004-08-01), Burli et al.
patent: 6903114 (2005-06-01), Backstrom et al.
patent: 2005/0171148 (2005-08-01), Majalli et al.
patent: 2006/0217416 (2006-09-01), Arend et al.
patent: 2134866 (1995-05-01), None
patent: 0650960 (1994-10-01), None
patent: 0650961 (1994-10-01), None
patent: 0650961 (1995-05-01), None
patent: 0911340 (1999-04-01), None
patent: A-H07-224039 (1995-08-01), None
patent: A-H07-228571 (1995-08-01), None
patent: A-H11-302257 (1999-11-01), None
patent: WO 1996/18616 (1996-06-01), None
patent: WO 01/58892 (2001-08-01), None
patent: WO 02/070510 (2002-09-01), None
patent: WO 02/100832 (2002-12-01), None
patent: WO 02/101073 (2002-12-01), None
patent: WO03/053997 (2003-07-01), None
patent: WO2004/052285 (2004-06-01), None
patent: WO 2004/108121 (2004-12-01), None
patent: WO 2004/108681 (2004-12-01), None
patent: WO 2005/007192 (2005-01-01), None
patent: WO 2005/009962 (2005-02-01), None
patent: WO 2005/011696 (2005-02-01), None
patent: WO 2005/014533 (2005-02-01), None
Franklin, et al. “Approaches to the design of anti-fibrotic drugs” Biochem. Soc. Trans. 19(4): 812-815 (1991).
Ivan, et al. “HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing”,Science, 292:464-468.
Lando, et al. “Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation”,Eur.J. Biochem, 270:781-790 (2003).
Richard, et al, “Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells”,J. Biol. Chm, 275:26765-26771 (2000).
Sandau, et al. “Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the P1 3K Pathway”Biochem. Biophys. Res. Commun.,278:263-267(2000).
Safran, et al. “HIF hydroxylation and the mammalian oxygen-sensing pathway”J. Clin. Invest.111(6):779-783 (2003).
Sodhi, et al. “MAPK and Akt Act Cooperatively but Independently on Hypoxia Inducible Factor-1α inrasV12 Unpregulation of VEGF”Biochem.Biophys. Res.Commun.,287:292-300 (2001).
Tacchini, et al. “Hepatocyte growth factor signaling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells”Carcinogenesis,22:1363-1371 (2001).
Sato et al. “Stability and Physicochemical Properties of Viracept Tablets”Antibiotics and Chemotherapy14(9):1589-1592 (1998)—English Translation Not Available.
U.S. Appl. No. 11/549,571, filed Oct. 13, 2006, Arend, et al.
U.S. Appl. No. 11/624,949, filed Jan. 19, 2007, Arend, et al.
Jaakkola P, et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292(5516):468-472.

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