Nitrogen containing heteroaromatics as factor Xa inhibitors

Details Nitrogen containing heteroaromatics as factor Xa inhibitors Nitrogen containing heteroaromatics as factor Xa inhibitors

1997-12-22

2000-02-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142365, 514255, 514326, 514341, 514359, 514371, 514381, 514383, 514394, 514397, 514407, 544140, 544371, 546211, 5462754, 548200, 548253, 548255, 5482662, 5483061, 5483124, 5483641, 5483651, 5483657, 5483697, 5483721, 5483725, 5483741, A61K 31415, A61K 3141, A61K 31495, A61K 31535, C07D40300, C07D40100, C07D23104, C07D27700

Patent

active

060203579

ABSTRACT:
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(.dbd.NH)NH.sub.2, which are useful as inhibitors of factor Xa.

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Tidwell et al., Journal of Medicinal Chemistry 1978, 21 (7), 613-623, "Diarylamidine Derivatives with One or Both of the Aryl Moieties Consisting of an Indole or Indole-like Ring. Inhibitors of Arginine-Specific Esteroproteases."

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