Nitrogen-containing compounds having kinase inhibitory...

Details Nitrogen-containing compounds having kinase inhibitory... Nitrogen-containing compounds having kinase inhibitory...

2007-05-15

2007-05-15

Davis, Zinna N. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S139000

Reexamination Certificate

active

10181943

ABSTRACT:
An objective of the present invention is to provide compounds having Rho kinase inhibitory activity. The compounds according to the present invention are those represented by formula (I) or pharmaceutically acceptable salts or solvates thereof:in-line-formulae description="In-line Formulae" end="lead"?Het—X—Z  (I)in-line-formulae description="In-line Formulae" end="tail"?wherein Het represents a monocyclic or bicyclic heterocyclic group containing at least one nitrogen atom, for example, pyridyl or phthalimide; X represents group (i) —NH—C(═O)—NH—Q1-, group (ii) —NH—C(═O)—Q2-, wherein Q1 and Q2 represent a bond, alkylene, or alkenylene, or the like; and Z represents hydrogen, halogen, a monocyclic, bicyclic, or tricyclic carbocyclic group, a heterocyclic group or the like, for example, optionally substituted phenyl.

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