Nitrogen-based stabilizers for 3-isothiazolones

Details Nitrogen-based stabilizers for 3-isothiazolones Nitrogen-based stabilizers for 3-isothiazolones

1992-08-11

1994-08-30

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514338, 514342, 514372, 514373, 548206, 548207, 548214, A01N 4336, A01N 4338, C07D27502

Patent

active

053428366

ABSTRACT:
A method of protecting 3-isothiazolones of the formula: ##STR1## wherein Y is (C.sub.1 -C.sub.18)alkyl or (C.sub.3 -C.sub.12)cycloalkyl each optionally substituted with one or more of hydroxy, halo, cyano, alkylamino, dialkylamine, arylamino, carboxy, carbalkoxy, alkoxy, aryloxy, alkylthio, arylthio, haloalkoxy, cycloaklylamino, carbamoxy, or isothiazolonyl; an unsubstituted or halo-substituted (C.sub.2 -C.sub.8)alkenyl or alkynyl; a (C.sub.7 -C.sub.10)aralkyl optionally substituted with one or more of halogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy; and an aryl optionally substituted with one or more of halogen, nitro, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkyl-acylamino, carb(C.sub.1 -C.sub.4)alkoxy or sulfamyl; and R and R.sup.1 is each independently H, halogen (C.sub.1 -C.sub.4)alkyl, (C.sub.4 -C.sub.8) cycloalkyl or joined together to form a phenyl; comprising incorporating therewith an effective amount of a nitrogen-containing, sulphur-free compound, capable of reversibly associating with said isothiazolone.
The compounds and compositions are also described.

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