Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-12-24
1988-10-18
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546152, 549 62, 549 64, 549 70, 549 71, A61K 3147, C07D21514
Patent
active
047788038
ABSTRACT:
The invention relates to new nitrogen-arylmethoxy-thiophene derivatives of the formula I ##STR1## wherein the R--CH.sub.2 --O-group is in position 4 or 5 of the thiophene ring, R denotes a 2-pyridinyl- or 2-quinolinyl group and R.sub.1 denotes a --COO-lower alkyl-, --CO--(CH.sub.2)n--CH.sub.3 or --CH(OH)--(CH.sub.2).sub.n --CH.sub.3 group, wherein n represents an integer from 2 to 6, and their hydrates and/or their pharmaceutically acceptable acid addition salts, a process for their preparation and pharmaceutical products containing these compounds. The new compounds and their salts have useful pharmacological properties. They can be used as active compounds for medicaments for the treatment and prevention of diseases, caused by a disturbance in arachidonic acid metabolism.
REFERENCES:
patent: 4292320 (1981-09-01), Kishimoto et al.
patent: 4329352 (1982-05-01), Frickel et al.
patent: 4631287 (1986-12-01), Chakraborty
Chemical Abstracts, vol. 88, Column 136507v (1978).
Binder Dieter
Ferber Hubert P.
Rovenszky Franz
Schror Karsten
Chemie Linz Aktiengesellschaft
Daus Donald G.
Noel Mark W.
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